Authors say one explanation for the trend is untreated withdrawal with more severe opioid use disorder

Posttraumatic stress disorder symptoms associated with suicidal ideation, with PTSD a full mediator between discrimination and suicide

Based on moderate-quality evidence, direct association seen for greater intensity of behavioral therapy with efficacy findings

Increasing distress also seen with increased housing and food insecurity among women with breast cancer

However, patients on antidepressants found to have worse symptoms and medication adherence

However, an elevated neuroticism sum score can be a causative factor for the disease

Use more likely among unmarried or unpartnered adults and those consuming alcohol

Factors include social isolation, diabetes, heart disease, vitamin D deficiency, high C-reactive protein, and low handgrip strength

Findings seen for patients undergoing repetitive treatment for major depressive disorder

Increased risk seen in association with benzodiazepines ranging from odds ratios of 1.39 to 2.52 for alprazolam and fludiazepam