Threefold increase seen in unintentional drug overdose death rates from 2003 to 2019, followed by 58 percent increase through 2022

Five differential metabolites had AUC values greater than 0.7 for diagnosing tardive dyskinesia in schizophrenia

Annual increase of 0.24 percentage points seen in children aged 5 to 17 years and of 0.33 percentage points for young adults age 18 to 25 years

Increase in prevalence seen for internalizing behavior, while decreases seen in sexual risk behaviors and substance use

Severe adverse events, including death, can occur if used for recreational or nonfood purposes

Exposures increased 924.3 percent in those aged 0 to 12 years, with most exposures unintentional