Most predominant causes of increased DALY burden globally were seen for depressive and anxiety disorders, especially among women and girls

Prevalence higher for current depressive symptoms and current anxiety symptoms

Link to more depressive symptoms during early adolescence could potentially be due to shorter sleep and worse white matter organization

No significant changes seen in sleep, mood, quality of life for TRE versus usual care, regardless of timing of the eating window

Agency will require a Limitation of Use section in the prescribing information of all extended-release ADHD stimulants

Magnitude of these associations decreases alongside increasing prescription rates

Increased risk for consumption seen during periods of rising estradiol levels

Participants with LLMDs more likely to be tau PET- and amyloid β PET-positive compared with healthy controls

High or increasing trajectories of addictive use of social media, mobile phones, or video games are common among adolescents