Proposal suggests lowering nicotine levels in cigarettes and other tobacco products to minimally or nonaddictive levels

Measures of continuous formulations quantifying job strain show best performance

Compared with males, females have lower odds of being formally diagnosed, have later age at symptom onset and diagnosis

Review shows benefit for cutting risk for onset of major depressive disorder by 42 percent

Rates of lifetime completed forced sexual intercourse and past-year violence were higher for girls than boys

Number of U.S. adults who will develop dementia each year projected to increase from ~514,000 to 1 million; lifetime risk is 42 percent after 55 years of age

Association with depression attenuated in later years, while new sociodemographic risk factors emerged

Review findings include benefits for pregnant women

Inclusion of all mental health measures yields very modest increase in C-index and specificity, with no change in sensitivity

Fifteen candidate genes account for only 0.40 percent of variation in opioid use disorder risk