Small effects seen for improved fecal calprotectin and C-reactive protein
Patients with persistent, worsening symptoms more likely to have had IBD diagnosis within 12 months and higher disease activity
Genetically predicted BD significantly positively associated with risk for inflammatory bowel disease
Increased risk also seen among unaffected siblings of patients with either depression or IBD
Increased rates of glucocorticoid prescription or flare, escalation, death for those with clinical activity, symptoms of a common mental disorder