However, from 2013 to 2023, there was a decrease in heroin concentration
More median nonfatal overdoses from any drug reported for IMF or heroin users reporting xylazine use versus those not reporting xylazine use
Plurality of seizures in West, with 77.8 percent of seizures in the West in pill form
Significant increases reported in frequency, size of seizures across all regions of the United States
Trip killers were mainly discussed in reference to LSD, psilocybin mushrooms, and 3,4-methylenedioxymethamphetamine
Significant benefit seen as early as eight days compared with placebo
Cannabis most common illicit drug, but polysubstance use also common
Monthly percentage of illicitly manufactured fentanyl-involved deaths with xylazine detected increased from 2.9 to 10.9 percent
Increase seen in age-adjusted rate of drug overdose deaths involving xylazine from 0.03 to 1.06 per 100,000 standard population
Higher use seen among males, White people, and those from higher socioeconomic backgrounds