Rates of increase were higher among women than men, with 2018 to 2020 age-adjusted mortality rates up by 14.7 versus 12.5 percent
Age-adjusted rate of overdose deaths involving cocaine and opioids increased more quickly than cocaine alone from 2011 to 2021
83 percent of deaths due to external causes were excess, while 51 percent of deaths due to somatic causes were excess
Association partially mediated by neighborhood-level socioeconomic factors
Increased risk found for mortality from infections and suicide, while risk for mortality from cancer is reduced
Years of life lost due to opioid toxicity plateaued between 2017 and 2019, then increased through 2021
Suicide rate tripled for those aged 10 to 14 years from 2007 to 2018, while homicide rates doubled from 2016 to 2021
Findings seen across drug types and most ages, even when accounting for rates of drug misuse
Fifty-six countries from six continents surpassed U.S. life expectancy during 1933 to 2021
Premature adult mortality before age 70 years seen in study of middle-aged women followed for 18 years