Suicide rate tripled for those aged 10 to 14 years from 2007 to 2018, while homicide rates doubled from 2016 to 2021

Findings seen across drug types and most ages, even when accounting for rates of drug misuse

Fifty-six countries from six continents surpassed U.S. life expectancy during 1933 to 2021

Premature adult mortality before age 70 years seen in study of middle-aged women followed for 18 years

Decrease also seen in estimated age-adjusted COVID-19 death rate, from 115.6 to 63.1 per 100,000 persons

However, fewer than one in 20 individuals receive buprenorphine

Themes include searching for answers and processing cause of death, incidental implications of SCD event

While COVID-19 drove this excess in 2021, nearly half of excess deaths were from other causes

One in 370 deaths among older adults was caused by an overdose in 2021

Standardized mortality rate increased for those receiving monotherapy, those receiving four or more meds, those without comorbidities