COVID-19 will remain the third-largest killer for 2022, behind heart disease and cancer, even with the reduced numbers

Overdose mortality increased about 81 percent from 2017 to 2020 among pregnant and postpartum women

Rates of alcohol-induced deaths in 2020 increased with age, peaking for those aged 55 to 64 years

Rate even higher among younger adults aged 20 to 49 years, with an estimated one in five deaths

Unclear whether the S-Elixhauser comorbidity score offers an advantage over other similar measures

Family Instability,Poverty & Crowded Housing, and Poverty & Parental Separation clusters linked to increased risk

Declines in life expectancy seen for males and females, and for all race and Hispanic-origin groups

State laws preempting local authority to mandate paid sick leave may contribute to increased mortality in working-age adults

Higher risks for death, mechanical ventilation, and major cardiovascular event all independent of sociodemographic factors and medical history

Mortality rate increased more than threefold between 1999 and 2019