Risk for seizures increased with concomitant use of tramadol with CYP2D6-inhibiting versus neutral antidepressants
Findings seen for all strokes, ischemic strokes, and hemorrhagic strokes
Does not improve primary outcome, but did improve performance on certain cognitive tasks in those with epileptiform activity
Current evidence does not support increased suicidality for certain newer antiseizure medications; class warning may not be merited