2019 to 2021 saw increase in prevalence for certain demographic groups, including female high school students
Increases in rates of 73.0, 48.8, and 36.8 percent seen for children aged 10 to 12 years, 13 to 15 years, and girls
However, most cases involved more than one substance
Rates increased from 2001 to 2018, then decreased through 2020 and increased in 2021
Emergency department visit rate higher among males than females; peaked at age 35 to 44 years in males and at 14 to 18 years in females
Significant associations seen for suicide deaths with opioid prescriptions per capita, having any, high-dose, long-term opioid prescription
Prepandemic loneliness and lower purpose in life were the strongest predictors of new-onset suicidal ideation
However, no significant decrease seen in suicidal ideation or mortality between exercise and control groups
Car crash fatalities up in these states, but opioid overdose deaths down
Findings seen in analysis of 11 million pediatric emergency visits across 18 countries, with some differences by sex and age