Warnings for youth resulted in marked increases in psychotropic drug poisonings and suicide deaths

Proportion of telehealth prescriptions climbed across medications

Only high-dose psilocybin was better than placebo in antidepressant trials of escitalopram

Patients treated with antidepressants whose symptoms do not improve show more relapses in alcohol use disorder

CYP2D6-inhibiting antidepressants linked to worse outcomes than CYP2D6-neutral antidepressants when used with CYP2D6-metabolizing opioids

Higher risk seen for gaining weight with escitalopram, paroxetine, duloxetine; lower risk with bupropion

Higher frequencies of discontinuation symptoms seen in association with desvenlafaxine, venlafaxine, imipramine, and escitalopram

Bipolar diagnosis substantially cuts inpatient care in all age groups, which coincided with drop in antidepressant use

Authors find 19 percent increased risk for antidepressant Rx among previously naive adults

Rate increased by 17.0 percent per month before March 2020; increased 63.5 percent faster from March 2020 onward