In 11 comparisons, antidepressants were efficacious, but they were inefficacious or evidence was inconclusive for 31 comparisons
Only crude associations seen between risk for neurodevelopmental outcomes and exposure to antidepressants
Hypothesis that depression is caused by low serotonin not supported; some evidence shows decrease in serotonin with antidepressant use
Maternal use of SSRIs, SNRIs in first trimester of pregnancy not linked to increased risk for neonatal seizures or childhood epilepsy in offspring
No improvement seen in physical or mental health-related quality of life
<p>Combinations using an antagonist of presynaptic α2-autoreceptors may be an option for depression that does not respond to monotherapy</p>
<p>Greatest decline in incident stimulant and anxiolytic/sedative-hypnotic medications was in quarter 2 of 2020</p>
<p>Relative risks for mortality significantly reduced for any SSRI, fluoxetine, and fluoxetine or fluvoxamine</p>
<p>In randomized, double-blind trial, no difference seen in scores for agitated behaviors at 12 weeks with mirtazapine versus placebo</p>
<p>Nearly one in four people with type 2 diabetes in Scotland were prescribed antidepressants before a diabetes diagnosis</p>