Only crude associations seen between risk for neurodevelopmental outcomes and exposure to antidepressants
Hypothesis that depression is caused by low serotonin not supported; some evidence shows decrease in serotonin with antidepressant use
Maternal use of SSRIs, SNRIs in first trimester of pregnancy not linked to increased risk for neonatal seizures or childhood epilepsy in offspring
No improvement seen in physical or mental health-related quality of life
Combinations using an antagonist of presynaptic α2-autoreceptors may be an option for depression that does not respond to monotherapy
Greatest decline in incident stimulant and anxiolytic/sedative-hypnotic medications was in quarter 2 of 2020
Relative risks for mortality significantly reduced for any SSRI, fluoxetine, and fluoxetine or fluvoxamine
In randomized, double-blind trial, no difference seen in scores for agitated behaviors at 12 weeks with mirtazapine versus placebo
Nearly one in four people with type 2 diabetes in Scotland were prescribed antidepressants before a diabetes diagnosis
Relapse occurred in fewer patients who maintained their antidepressant treatment versus those with discontinuation