Increase in cannabis poisoning seen with medical cannabis laws and recreational cannabis laws
CBD did not meet primary end point comparing preingestion to postingestion anxiety, but resulted in lower anxiety levels
Increase driven by individuals living in jurisdictions that permitted adult-use retailers
Age-corrected standard scores for children's attention and inhibitory control lower for those exposed to cannabis
Higher odds of past-month cannabis use linked to residing in states where cannabis is legal, past-year depressive episode
Greatest rates seen in states or territories with both adult and medical use legalization
Nadir in use was reported in 1992, with partial recovery through 2008 and substantial increases thereafter
Risk increased for attention-deficit/hyperactivity disorder, autism spectrum disorder, and intellectual disability
Proportion of patient-reported qualifying conditions with substantial, conclusive evidence of therapeutic value decreased
Prevalence was lower in Western versus Southern census regions, in states with regulations, in states with legal adult-use marijuana