Increase in cannabis poisoning seen with medical cannabis laws and recreational cannabis laws

CBD did not meet primary end point comparing preingestion to postingestion anxiety, but resulted in lower anxiety levels

Increase driven by individuals living in jurisdictions that permitted adult-use retailers

Age-corrected standard scores for children's attention and inhibitory control lower for those exposed to cannabis

Higher odds of past-month cannabis use linked to residing in states where cannabis is legal, past-year depressive episode

Greatest rates seen in states or territories with both adult and medical use legalization

Nadir in use was reported in 1992, with partial recovery through 2008 and substantial increases thereafter

Risk increased for attention-deficit/hyperactivity disorder, autism spectrum disorder, and intellectual disability

Proportion of patient-reported qualifying conditions with substantial, conclusive evidence of therapeutic value decreased

Prevalence was lower in Western versus Southern census regions, in states with regulations, in states with legal adult-use marijuana