Review shows benefits for social responsiveness, disruptive behavior, and anxiety

Commercial administrative claims data show slight increase in annual prevalence from 2015 to 2020

Risk for death higher for individuals with hospital-based care for alcohol, stimulant, opioids versus cannabis use disorder

Schizophrenia-associated increase seen from prelegalization to legalization of nonmedical cannabis periods

Anterior insula, medial prefrontal cortex, and dorsolateral prefrontal cortex associated with history of heavy use

Findings seen for younger adults across cannabis use disorder severity levels

For individuals reporting past-year cannabis use, decreased odds of opioid misuse observed in states with medical cannabis legalization

Increase in cannabis poisoning seen with medical cannabis laws and recreational cannabis laws