Monotonic increase in dementia risk with greater alcohol consumption seen in Mendelian randomization genetic analysis

After adjustment for adult loneliness, childhood loneliness linked to cognitive decline and dementia risk

Highest posterior probabilities seen with mood and anxiety disorder co-occurrence

Significantly greater benefit on global cognition seen for structured versus self-guided intervention over two years

Participants with LLMDs more likely to be tau PET- and amyloid β PET-positive compared with healthy controls

Shorter leukocyte telomere length linked to higher incidence rates of stroke, dementia, late-life depression as composite and individually

Depression present in late life and midlife linked to significantly increased risk for all-cause dementia

Overall, 79 percent of Americans would want to know if they had Alzheimer disease before experiencing symptoms or before symptoms interfere

Compared with those with all-cause hospital-based care and the general population, risk increased for those with cannabis use-based care

Authors say these factors can inform steps individuals can take to lower their risks for age-related brain diseases