High levels of anxiety, depression, stigma, and impaired QoL reported by many patients; all linked to perceptions of illness

No association seen between depressive symptoms and use of estrogen plus progestogen therapy

Endotoxin induced increases in Profiles of Mood States depression subscale to a greater extent in those with insomnia

Insomnia severity only partially mediates the relationship between ADHD traits and lower quality of life in adults

Those with remission at preadolescence have lower lifetime use of antipsychotics and intensive mental health interventions

Most predominant causes of increased DALY burden globally were seen for depressive and anxiety disorders, especially among women and girls

Prevalence higher for current depressive symptoms and current anxiety symptoms

Participants with LLMDs more likely to be tau PET- and amyloid β PET-positive compared with healthy controls

Associations generally stronger for postnatal than antenatal mental distress

Findings seen for both suicide and overall mortality, with even stronger effects seen in more recent studies