Ketamine use outside of acute pain management and procedural sedation should be part of comprehensive treatment plan by trained medical professionals

Risk particularly heightened in men, but seen across kidney disease stages

Modestly lower risk for depression seen compared with DPP-4i use, but not compared with SGLT-2i use

Findings seen both at baseline and for developing new conditions over time, even when adjusting for sociodemographic and lifestyle factors

Fewer depressive symptoms and better mental health associated with higher psychological resilience

Reproductive health may be the pathway linking traffic-related air pollution to depression

Drug is the first and only approved monotherapy for refractory major depressive disorder

Overall, retirement associated with higher levels of depression

Review shows benefit for cutting risk for onset of major depressive disorder by 42 percent

Association with depression attenuated in later years, while new sociodemographic risk factors emerged