In the context of coaching calls, neither nicotine replacement therapy nor mHealth interventions significantly add to the quit rate

Most dual users either continue dual use or transition to exclusive conventional cigarette use

Those who switch to dual use or who maintain, increase smoking intensity have reduced rate of symptom resolution

Most common modifications to disposable pods were refilling and recharging the battery

Significantly more patients receiving cytisinicline versus placebo had continuous e-cigarette abstinence at the end of treatment

Vaping tied to greater cigarette quitting in more recent years

However, ongoing use of e-cigarettes with nicotine was high

Quit rate higher for ECs than nicotine replacement therapy; at six months, 62.8 percent in EC arm still using ECs

Combination of a patch and fast-acting nicotine replacement therapy also effective