Since 2020, fatal synthetic opioid-only overdose rates higher than polydrug overdose rates involving synthetic opioids
Declines seen across drug classes and for most states
Trends increased among most demographic groups through mid-2023, with largest increase seen for non-Hispanic American Indian, Alaska Native persons
Exposures increased 924.3 percent in those aged 0 to 12 years, with most exposures unintentional
This trend may be driven by increases in heroin and synthetic opioids coinvolvement
2023 to 2024 saw approximately sevenfold increase in overdose deaths involving carfentanil
However, from 2013 to 2023, there was a decrease in heroin concentration
Findings seen for doses >16 mg and emergency department or inpatient utilization