Significant declines seen across genders, races/ethnicities

Higher odds of past-month cannabis use linked to residing in states where cannabis is legal, past-year depressive episode

Prevalence was lower in Western versus Southern census regions, in states with regulations, in states with legal adult-use marijuana

Use more likely among unmarried or unpartnered adults and those consuming alcohol

Daily use of cigarettes, e-cigarettes, and cannabis associated with both anxiety and depression

Prevalence highest in current e-cigarette users and Hispanic and sexual minority populations

However, coinciding increases in binge drinking seen among adults ≥31 years

Higher risk for psychotic versus nonpsychotic subtypes of bipolar disorder seen in association with CUD