Vaping and dabbing are the most prevalent routes of use among persons aged 18 to 24 years
Significant declines seen across genders, races/ethnicities
Higher odds of past-month cannabis use linked to residing in states where cannabis is legal, past-year depressive episode
Prevalence was lower in Western versus Southern census regions, in states with regulations, in states with legal adult-use marijuana
Use more likely among unmarried or unpartnered adults and those consuming alcohol
Daily use of cigarettes, e-cigarettes, and cannabis associated with both anxiety and depression
Prevalence highest in current e-cigarette users and Hispanic and sexual minority populations
However, coinciding increases in binge drinking seen among adults ≥31 years