Declines seen across drug classes and for most states
This trend may be driven by increases in heroin and synthetic opioids coinvolvement
However, from 2013 to 2023, there was a decrease in heroin concentration
Regardless of prognosis, panel deemed it appropriate to continue opioids, increase monitoring, and avoid opioid tapering
Increase seen in age-adjusted drug overdose death rates involving methamphetamine, cocaine; decrease reported in death rates involving oxycodone
Proportion of deaths co-involving methamphetamine and heroin or fentanyl peaked at 61.2 percent in 2021
MethHF linked to significant morbidity, including worse heart failure symptoms compared with non-methamphetamine-related heart failure
Rural U.S. residents who use both drugs more likely to have nonfatal overdose than those who use either drug alone
From 2007 to 2019, opioid-stimulant deaths among Black people increased at more than three times the rate of White people
This was the first public safety alert the DEA has issued in six years