Significant increase seen in crude nitrous oxide poisoning rate from 2010 to 2018, but no increase seen from 2019 to 2023
Opioids are most often the drug class implicated in causing death
Benefits include lower risk for death and cardiovascular disease, diabetes, dementia, and depression
Relatives of bereaved in high grief trajectory have increased use of mental health services, antidepressants, sedatives, and anxiolytics
Monthly DOD rate declined by −0.36 per 100,000 from August 2023 to February 2024, accelerating through October 2024
Findings seen for both suicide and overall mortality, with even stronger effects seen in more recent studies
Increased mortality seen in association with longer nap duration, greater intraindividual variability, more naps from 11 a.m. to 1 p.m., 1 to 3 p.m.
Since 2020, fatal synthetic opioid-only overdose rates higher than polydrug overdose rates involving synthetic opioids
U.S. mortality rose rapidly in 2020 and 2021, then declined in 2022 and 2023, remaining higher than in 2019
After adjustment for demographic and health variables, hazard ratio was 1.94 for individuals with epilepsy and sleep deprivation