Since 2020, fatal synthetic opioid-only overdose rates higher than polydrug overdose rates involving synthetic opioids

U.S. mortality rose rapidly in 2020 and 2021, then declined in 2022 and 2023, remaining higher than in 2019

After adjustment for demographic and health variables, hazard ratio was 1.94 for individuals with epilepsy and sleep deprivation

Declines seen across drug classes and for most states

Overall, 79 percent of Americans would want to know if they had Alzheimer disease before experiencing symptoms or before symptoms interfere

Black men and Black women have pronounced and increasing burden of mortality compared with Whites

Threefold increase seen in unintentional drug overdose death rates from 2003 to 2019, followed by 58 percent increase through 2022

Suboptimal sleep trajectory linked to an increased risk for all-cause mortality

Mortality rates due to suicide highest in Eastern Europe, Southern and Central sub-Saharan Africa

People with acute care involving hallucinogens have greater risk for death by unintentional drug poisoning, suicide