Threefold increase seen in unintentional drug overdose death rates from 2003 to 2019, followed by 58 percent increase through 2022

Suboptimal sleep trajectory linked to an increased risk for all-cause mortality

Mortality rates due to suicide highest in Eastern Europe, Southern and Central sub-Saharan Africa

People with acute care involving hallucinogens have greater risk for death by unintentional drug poisoning, suicide

Multiorgan consequences of COVID-19 persist through 30 months after discharge

Highest rates in 2023 seen in West Virginia, District of Columbia; changes in rates varied by jurisdiction across drug types

Risk for death higher for individuals with hospital-based care for alcohol, stimulant, opioids versus cannabis use disorder

Early adult excess mortality higher than expected in 2019

This trend may be driven by increases in heroin and synthetic opioids coinvolvement

Results also showed age-adjusted rate of drug overdose deaths decreased from 2022 to 2023, after increasing over 20 years