Authors say findings support efforts to improve social isolation, loneliness
Increased hazard ratios seen for all-cause mortality and mortality due to natural and unnatural causes
Diagnosis of bipolar disorder increased odds of mortality more than history of smoking or age 60 years or older
Mortality ratio increased about threefold for pregnant and postpartum women aged 35 to 44 years
Risk for death was found to be exacerbated by comorbidities
Inverse association did not differ with caregiving frequency or when stratified by age, race-ethnicity, depressive symptoms
Increased risk seen for all-cause mortality and cardiovascular disease mortality, with links consistent across subgroups
Opioid crisis hitting those without college education the hardest
2018 to 2021 saw 41.6 percent increase in firearm death rate; 82.6 percent of deaths were in children aged 15 to 19 years
Cannabis most common illicit drug, but polysubstance use also common