Meta-analysis of three COSMOS substudies shows evidence of benefits on global cognition, episodic memory
Based on moderate-quality evidence, direct association seen for greater intensity of behavioral therapy with efficacy findings
Prevalence of melatonin consumption significantly higher for school-aged children, preteens versus preschool children
<p>Analysis shows most exceed the declared amount of melatonin and cannabidiol and may expose children to very high doses</p>
Risk for self-harm reduced after initiation of melatonin, especially among adolescents with depression/anxiety
Any vitamin D supplement exposure was associated with 40 percent lower dementia incidence
<p>Authors say more research is needed to determine the benefits of supplementation with standard treatment</p>
<p>But evidence suggests that reverse causation may play a role in the links between serum folate deficiency and dementia, all-cause mortality</p>
<p>1999-2000 to 2017-2018 saw increase in reported prevalence of melatonin use across sex and age groups</p>
<p>Small increase in risk for depression or clinically relevant depressive symptoms but no difference in mood scores seen with long-term use</p>