Significant increase seen in prepandemic EMS encounters, followed by immediate, significant increase with pandemic interruption

Proportion of telehealth prescriptions climbed across medications

Clinicians and policymakers need a more accurate estimate of the prevalence of problematic opioid use, authors say

CYP2D6-inhibiting antidepressants linked to worse outcomes than CYP2D6-neutral antidepressants when used with CYP2D6-metabolizing opioids

No significant reduction seen in opioid overdose deaths with implementation of evidence-based practice strategies

Prenatal opioid exposure not linked to a clinically meaningful increase in risk for neuropsychiatric disorders

Authors say one explanation for the trend is untreated withdrawal with more severe opioid use disorder

Increase tied to decline in living conditions for children, not illicit opioid use

The American Medical Association calls for action on eight strategies to increase access to evidence-based opioid use disorder care