CYP2D6-inhibiting antidepressants linked to worse outcomes than CYP2D6-neutral antidepressants when used with CYP2D6-metabolizing opioids
No significant reduction seen in opioid overdose deaths with implementation of evidence-based practice strategies
Prenatal opioid exposure not linked to a clinically meaningful increase in risk for neuropsychiatric disorders
Authors say one explanation for the trend is untreated withdrawal with more severe opioid use disorder
Increase tied to decline in living conditions for children, not illicit opioid use
The American Medical Association calls for action on eight strategies to increase access to evidence-based opioid use disorder care
Rapid induction to extended-release buprenorphine 300-mg injection feasible and well tolerated for those using fentanyl
Predictors include history of overdose, higher opioid dose, three or more prescribers, any mental health diagnosis
Higher 90-day treatment retention rates seen with no higher risk for overdose