This was the first public safety alert the DEA has issued in six years

History of TBI tied to 52 percent increased odds of prescription opioid use, 65 percent increased odds of prescription opioid misuse

In 2019, xylazine contributed to death in 64 percent of cases and almost always also involved fentanyl

No significant change seen in overdose death rates overall from 2018 to 2019, but rate increased among non-Hispanic Blacks

Hospitalizations for cardiac arrest with opioid use linked to higher prevalence of alcohol, depression, and smoking

Sackler family to pay $4.5 billion in bankruptcy settlement, denies any personal responsibility

When asked if he carries any responsibility for the opioid crisis in the United States, Richard Sackler firmly replied: 'No'

Rates of overdose, mental health crises increased after dose tapering among patients prescribed stable, long-term, higher-dose opioid therapy

Money to be used by communities for addiction treatment, prevention services, and other significant costs associated with the epidemic

High-dose buprenorphine protocol well tolerated in patients with untreated opioid use disorder; no reports of respiratory depression or sedation