Updated opioid safety labeling is based on new data from two large postmarketing observational studies
Opioids are most often the drug class implicated in causing death
Findings seen for Black patients presenting to the emergency department
Monthly DOD rate declined by −0.36 per 100,000 from August 2023 to February 2024, accelerating through October 2024
Since 2020, fatal synthetic opioid-only overdose rates higher than polydrug overdose rates involving synthetic opioids
Declines seen across drug classes and for most states
Trends increased among most demographic groups through mid-2023, with largest increase seen for non-Hispanic American Indian, Alaska Native persons
Black men and Black women have pronounced and increasing burden of mortality compared with Whites
Highest percentage of cocaine co-involvement seen in industries that are less physically strenuous
Threefold increase seen in unintentional drug overdose death rates from 2003 to 2019, followed by 58 percent increase through 2022