Sales are a fraction of pharmacy-dispensed and program-distributed naloxone
People who died of overdoses involving stimulants and no opioids were older, more often had history of CVD
Updated opioid safety labeling is based on new data from two large postmarketing observational studies
Opioids are most often the drug class implicated in causing death
Findings seen for Black patients presenting to the emergency department
Monthly DOD rate declined by −0.36 per 100,000 from August 2023 to February 2024, accelerating through October 2024
Since 2020, fatal synthetic opioid-only overdose rates higher than polydrug overdose rates involving synthetic opioids
Declines seen across drug classes and for most states
Trends increased among most demographic groups through mid-2023, with largest increase seen for non-Hispanic American Indian, Alaska Native persons
Black men and Black women have pronounced and increasing burden of mortality compared with Whites