Strong recommendation made against long-term opioid therapy, especially for younger age groups, those with substance use disorder

In 11 comparisons, antidepressants were efficacious, but they were inefficacious or evidence was inconclusive for 31 comparisons

Universal screening for cannabinoids recommended before surgery; elective surgery should be postponed in some cases

Text message-based platform enhances self-efficacy for managing symptoms of IC/bladder pain syndrome

Tapering cuts risk for overdose among those with opioid use disorder

Chronic pain at age 44 years linked to poor mental health outcomes, pessimism about future, joblessness at age 55 years

However, no significant differences seen in opioid use postoperatively between cannabis users and nonusers

In survey, some patients report less pain, better physical and social functioning after using medical cannabis

Palliative and addiction medicine specialists provide consensus-based guidance for three common clinical scenarios

Moderate improvement in pain severity and response for products with high THC-to-CBD ratios, but side effects are seen