Rural U.S. residents who use both drugs more likely to have nonfatal overdose than those who use either drug alone

Eutylone-involved deaths frequently co-involved illicitly manufactured fentanyls, and cocaine or methamphetamine

Overdose rate in 2020 nearly seven times higher for Black versus White men aged 65 years and older

Increase in methadone-involved deaths in March 2020 not thought to be tied to expanded opioid treatment program take-home policies

Authors hope findings will 'inform a more cautious approach to decisions around opioid dose tapering'

Easy access to over-the-counter medications may play a role in their use for suspected suicides

Yet, study shows buprenorphine is effective in protecting against overdose in this population

However, growth in overdose deaths has slowed compared with the 30 percent increase seen in 2020

Counterfeit pills contain the synthetic opioid fentanyl and are fueling increases in overdoses and hospitalizations

A shift in the age distribution of opioid-related mortality has occurred with the highest rates now observed in younger individuals